Comprehensive or Complementary to Existing Care

Synapticure partners with primary care physicians and with general cognitive specialists to provide subspecialty neurology care and wraparound services

Proven Outcomes with Synapticure

After  6+ months enrolled vs. 12 months prior to Synapticure.

~2 weeks

From intake to appointment

Get in front of a subspecialty 
neurologist fast

+96 NPS

Net Promoter Score

Families rate the experience 
“world-class”

19% fewer

Emergency room trips

Proactive care slashes crisis 
visits and costs

## The Synapticure 
Workflow

1

Evaluation and Diagnostics

Clinically-validated diagnostics, but with less disruption and potentially a more consistent results

• Provide personalized support throughout the entire journey, lightening the burden of managing neurodegenerative care
• Handles all logistics for virtual appointments ensuring fast access and minimizing stress
• When in-person care is necessary, the CC schedules and coordinates seamlessly with local providers to reduce caregiver burden

Standard Clinically-Validated Diagnostic Evaluation

Synapticure delivers best-in-class diagnostic testing

• Research supports that telehealth assessments, inclusive of neurocognitive testing, may yield more precise results by keeping patients calm and oriented in their natural home setting. Peer-reviewed studies, including the Alzheimer’s Journal, confirm there is no difference in diagnostic validity between telehealth and in-person evaluations

Standardized Assessment with NIH Stroke Scale (NIHSS)

• Synapticure integrates the NIH Stroke Scale at intake and at each follow-up visit, ensuring a reproducible baseline examination that forms the foundation for a consistent safety framework for remote treatment

Comprehensive neuro intake performed by a Synapticure cognitive specialist

• Mental Status Exam: Appearance, speech, eye contact, motor activity, affect, mood, behavior, delusions, hallucinations, orientation, memory, attention, thoughts
• Cranial Nerve Exam: Vision (each eye independently), EOM, hearing, facial, Trigeminal, tongue thrust and movement
• Motor and Sensory Exam: Passive strength, and can be limited by ability to stand
• Cerebellar Exam: Can be limited by ability to stand
• Standardized Scale for Reliable Safety Monitoring: Baseline NIHSS for continuity

2

Treatment and Trials Decision-Making Support

#### Multidisciplinary expert board, cutting-edge trial access, and 
hands-on care coordination to guide every treatment decision

• Provides guidance on clinical trial eligibility and logistics, making the process accessible and less daunting for families
• Organizes all follow-up visits related to treatment and trial participation

Care Decisions Backed by a Team of Specialists

• Multidisciplinary Review Board (MDRB): Synapticure’s unique review process, typically found only in leading academic centers, includes three Synapticure cognitive specialists and one Synapticure neuropsychologist for comprehensive, holistic assessments
• Ensures decisions aren’t made in isolation and are guided by the latest research and best practices

3

Safety and Monitoring

Accredited infusion care, expert-guided trial access, and proactive coordination that safeguards patients at every step

• Finds and arranges appointments at accredited infusion centers, ensuring compliance with safety and quality standards (e.g., NICA accreditation)
• Care Navigator assists in providing vital patient records and treatment history

Ensures Accreditation & High Standards

• Synapticure’s partnered infusion centers are accredited by organizations that require rigorous protocols for pre-treatment evaluation, emergency response, and post-treatment care
• NICA and/or joint commission accreditation
• Infusion centers can vary widely in their adherence to accreditation standards, leaving gaps in safety practices, protocol consistency, and care quality. We take the burden off patients by vetting and selecting only accredited sites, ensuring reliable and safe care every time.

4

Supporting Treatment Access

24/7 expert support, real-time emergency coordination, and ongoing monitoring to keep every treatment safe, seamless, and always within reach

• Ensures patients have round-the-clock access to experienced cognitive specialists for real-time advice and support
• Ensures patients receive follow-ups after treatments, addressing any safety concerns

Care and Treatment

24/7 Hotline Availability

• Our care team is always on call, ensuring that patients and care partners can speak to an experienced cognitive specialist the moment they experience unusual symptoms or have safety concerns

Real-Time Expert Support During Emergencies

• If emergency care is needed, our neurologists remain on the line as patients head to the ER, providing immediate reassurance and actionable advice on what to do next

Direct Communication with ER Teams

• Our cognitive specialists will speak directly with ER physicians, providing vital context about the patient’s condition, treatment plan, and any medication side effects

Access to Medical Records and Continuity of Care

• Synapticure ensures ER physicians have access to patient history, treatment records, and more.

Infusion Reaction Protocol (If Necessary)

Observation Instructions

Instructions are provided to observe the patient during the infusion for any reactions and then continue observation for:

• 3 hours post-infusion after the initial infusion
• 2 hours post-infusion after the 2nd infusion
• 1 hour post-infusion after each following infusion

Hypersensitivity Treatments

All accredited Infusion centers have a mandated treatment protocol for acute infusion reactions. In addition, we provide our recommended treatments for hypersensitivity for their use and include them in our order set including:

• If hypersensitivity or infusion reactions develop, temporarily hold the infusion and notify the site provider immediately
• Administer emergency medications per the site Treatment Algorithm for Acute Infusion Reaction. Symptom monitoring and continuous assessment per the site protocols with requisite documentation as the grade of severity may progress
• Synapticure can be contacted for assistance if needed to aid the site medical director and staff,  and the Infusion site is provided with our contact information and direct line

## Meet Our Clinical 
Leadership

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Eric Anderson

PhD MBA FAAN

Chief Medical Officer

Amanda Fletcher

MD

Director of Cognitive Neurology

Ben Williams

MD, FAAN

Cognitive Neurologist

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Abigail O’Connell

NP

Director of Clinical Trial Operations

Jeremy Pruzin

MD

Cognitive Neurologist

Tacara Soones

MD, MPH

Geriatrician

Noreen Flanagan

MD

Director of Mental and Behavioral Health

Mindy Unrau

FNP

Cognitive Nurse Practitioner

Comprehensive Neurology Care All in One Place

Schedule a consultation call with a Synapticure care coordinator to discuss 
your needs and learn how we can help.