Get started with Synapticure
Cutting-Edge Treatment
Welcome to the Synapticure community and thank you for taking the first steps to getting expert care for Dementia. We're truly honored to have you with us.
By registering, you’re not only exploring potential care options for yourself or a loved one — including access to cutting-edge treatments like Amyloid Therapies— you’re also contributing to research that could make a real difference for others facing similar challenges. We’re deeply grateful for your willingness to be part of this important work.
The Synapticure Way
When you begin your journey with us, you can expect to:
Schedule Intake
Book a no-cost virtual intake with us. We’ll answer questions, offer guidance and help with care navigation.
Meet Your Dedicated Care Team
You’ll meet our dedicated team of professionals, here to support you every step of the way. Our team are experts in amyloid therapies, and Alzheimer’s clinical trials.
Get a Care Plan
A personalized care plan is built around your daily needs at home.
Receive 24/7 Support
Receive day and night access to care coordination services.If you opt-in
Our Experts
Oleg Yerstein
Director of Cognitive Care Service Line, Neurologist
Former Director of the Center for Memory and Cognitive Disorders at Beth Israel Lahey Health, Dr. Yerstein brings extensive expertise in dementia biomarkers, anti-amyloid therapies, and Alzheimer’s clinical trials.
Noreen Flanagan
Director of Behavioral Health, Psychiatrist
Dr. Flanagan has dedicated over 20 years to neurodegenerative care, pioneering interdisciplinary programs in Memory Clinic and tele-psychiatry to ensure comprehensive care for all, now continuing her passion at Synapticure.
Jeremy Pruzin
Cognitive Neurologist
Dr. Jeremy Pruzin is a behavioral neurologist researching and treating Alzheimer’s and related dementias, with a focus on prevention through lifestyle and risk factor management.
In-network coverage for all 50 states
Please note that we may be considered out-of-network with your insurance provider. Coverage and reimbursement may vary depending on your specific plan. We recommend contacting your insurance company directly to confirm your out-of-network benefits before your visit. If you have any questions or need assistance with this process, our team is happy to help.
Frequently Asked Questions
Visit our full FAQ page for more commonly asked questions.
What are Amyloid Therapies?
Amyloid therapies, which currently include lecanemab and donanemab, are a new class of medications that work by clearing amyloid from the brain. Amyloid is a key protein that accumulates into abnormal plaques involved in Alzheimer’s disease.
How do I know if Amyloid Therapy is safe and right for me?
We’ll need the following records to help you make a decision on treatment:
Step 1: Confirm the Diagnosis. These therapies are only for people in the early stages of Alzheimer’s disease (mild cognitive impairment or mild dementia). They are not a cure, they slow the progression of symptoms by about 30-40%.
Step 2: Confirm pathologic accumulation of Amyloid in the Brain. Proof of amyloid buildup is required before treatment. This can be shown through:
- An amyloid PET scan, or
- A blood test (in some cases, to help guide next steps, though expect to need a spinal fluid or PET test in most cases to confirm eligibility).
Step 3: Complete a Safety Screen. We’ll need:
- MRI: A brain MRI to understand eligibility for treatment.
- Genetic testing: A genetic test for the APOE gene.
What should I know about the side effects of ARIA?
Risk for ARIA largely depends on a person's APOE genes and findings on the brain MRI prior to starting treatment.
How do I begin Amyloid Therapy?
Once your care team has confirmed the diagnosis, the presence of abnormal amyloid levels, and finished the safety screens, your case may need to be presented to our panel of clinical experts to approve treatment.
How often are treatments given?
These medications are given by IV infusion, either every 2 or every 4 weeks.
How long will I need treatments for?
Treatment decisions are individualized — your neurologist and care team will discuss the potential benefits and risks.
Patients and Caregivers Love Synapticure
Everyone from synapticure has been VERY helpful; from Eva and Dr. Jamie Hatcher. They are so kind and make you feel comfortable. They never rush you and they get things done so quickly.
Synapticure Patient
The support my wife and I have received from Synapticure since my PLS diagnosis in 2024 has been nothing short of exceptional.
Patient, Primary Lateral Sclerosis (PLS)
Synapticure has been an order of magnitude improvement in my care and scope of care (neurology plus behavioral health).
Patient, Parkinson's
We love the kindness and care from Rebecca and Dr. Jaimie Hatcher-Martin. Great service offered to ALS patients as well as Compassionate, help and understanding!!!
Caregiver, ALS
Great people all around. Taking great care of pALS and cALS. Predictable access and patient-centered support using a solid telehealth network.
Caregiver, ALS
Synapticure and support with speech therapy has been a true blessing in helping to care for my wife with Alzheimer's disease.
Caregiver, Alzheimer's
Thank you for the access to genetic testing! It was discovered that I had a mutation of the SOD1 gene which has completely changed my treatment.
Patient, ALS
Thank you for creating this wonderful healthcare system. You are life savers in a world where we need all the help we can get.
Patient, Parkinson's
Synapticure has been an order of magnitude improvement in my care and scope of care (neurology plus behavioral health). Discussions are always open and thorough.
Patient, Parkinson's
The support my wife and I have received from Synapticure since my PLS diagnosis in 2024 has been nothing short of exceptional.